Antiperadangan nonsteroid, (Bahasa Inggris: non-steroidal anti-inflammatory drugs, disingkat NSAIDs) atau obat antiinflamasi nonsteroid[2] (disingkat OAINS) adalah kelas obat yang sama-sama memberikan efek analgesik (antinyeri) dan antipiretik (penurun panas), dan dalam dosis yang lebih tinggi berefek anti-inflamasi. Istilah "nonsteroid" membedakan obat ini dari anti-inflamasi lain yaitu "steroid", yang bekerja menekan produksi eikosanoid. Istilah ini pertama kali digunakan pada tahun 1960, digunakan untuk menjauhkan obat baru dari tragedi iatrogenik terkait steroid.[3]
Klasifikasi
OAINS dapat diklasifikasikan berdasarkan struktur kimianya atau mekanisme aksi. OAINS lebih tua dikenal jauh sebelum mekanisme aksi mereka itu dijelaskan dan untuk alasan ini diklasifikasikan oleh struktur atau asal kimia. Zat baru lebih sering diklasifikasikan berdasarkan mekanisme aksi.
Turunan asam propionat
{{cite web | url = http://www.drugbank.ca/cgi-bin/getCard.cgi?CARD=APRD00372 | title =Ibuprofen | format = | work = DB01050 | publisher = DrugBank }}</ref>\n* [[Deksibuprofen]]\n* [[Naproksen]]\n* [[Fenoprofen]]\n* [[Ketoprofen]]\n* [[Deksketoprofen]]\n* [[Flurbiprofen]]\n* [[Oksaprozin]]\n* [[Loksoprofen]] (Loxonin), tersedia di Jepang.\n\n",{"template":{"target":{"wt":"colend","href":"./Templat:Colend"},"params":{},"i":1}}]}' id="mwMQ"/>
Turunan asam enolat (Oksikam)
''Consolidated List of products whose consumption and/or sale have been banned, withdrawn, severely restricted or not approved by Governments'', United Nations, 2003, p. 123 [http://apps.who.int/medicinedocs/en/m/abstract/Js16780e/ link to 2005 ed]</ref><ref>{{cite journal|last=Fung|first=M.|author2=Thornton, A. |author3=Mybeck, K. |author4=Wu, J. H.-h. |author5=Hornbuckle, K. |author6= Muniz, E. |title=Evaluation of the Characteristics of Safety Withdrawal of Prescription Drugs from Worldwide Pharmaceutical Markets-1960 to 1999|journal=[[Therapeutic Innovation & Regulatory Science]]|date=1 January 2001|volume=35|issue=1|pages=293–317|doi=10.1177/009286150103500134}}</ref>)\n* [[Fenilbutazon]] (Bute)\n",{"template":{"target":{"wt":"colend","href":"./Templat:Colend"},"params":{},"i":1}}]}' id="mwPA"/>
Penghambat siklooksigenase-2 selektif (koksib)
Information for Healthcare Professionals: Celecoxib (marketed as Celebrex) http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm124655.htm</ref>)\n* [[Rofekoksib]] (ditarik dari pasar<ref name=\"urlFDA Public Health Advisory: Safety of Vioxx\">{{cite web | url = http://www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformationforpatientsandproviders/ucm106274.htm | title = Safety of Vioxx | work = FDA Public Health Advisory | publisher = United States Food and Drug Administration }}</ref>)\n* [[Valdekoksib]] (ditarik dari pasar<ref>[http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm124649.htm Alert for Healthcare Professionals: Valdecoxib (marketed as Bextra)]</ref>)\n* [[Parekoksib]] ditarik FDA, berlisensi di EU\n* [[Lumirakoksib]] pendaftaran dibatalkan TGA (Australia)\n* [[Etorikoksib]] tidak disetujui FDA, berlisensi di EU\n* [[Firokoksib]] digunakan pada anjing dan kuda\n\n",{"template":{"target":{"wt":"colend","href":"./Templat:Colend"},"params":{},"i":1}}]}' id="mwXw"/>
Sulfonanilida
- Nimesulida (sediaan sistemik dilarang oleh beberapa negara karena potensi risiko hepatotoksisitas)
Referensi
- 1 2 Ghlichloo, Ida; Gerriets, Valerie (1 May 2023), "Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 31613522, diarsipkan dari versi aslinya tanggal 23 April 2024, diakses tanggal 2024-03-31
- 1 2 3 4 "non-steroidal anti-inflammatory drug". www.Lexico.com. Oxford English Dictionary. 2022. Diarsipkan dari asli tanggal 5 February 2022. Diakses tanggal 4 February 2022.
- ↑ Buer JK (Oct 2014). "Origins and impact of the term 'NSAID'". Inflammopharmacology. 22 (5): 263–7. doi:10.1007/s10787-014-0211-2. PMID 25064056.
- ↑ "Ibuprofen". DB01050. DrugBank.
- ↑ Consolidated List of products whose consumption and/or sale have been banned, withdrawn, severely restricted or not approved by Governments, United Nations, 2003, p. 123 link to 2005 ed
- ↑ Fung, M.; Thornton, A.; Mybeck, K.; Wu, J. H.-h.; Hornbuckle, K.; Muniz, E. (1 January 2001). "Evaluation of the Characteristics of Safety Withdrawal of Prescription Drugs from Worldwide Pharmaceutical Markets-1960 to 1999". Therapeutic Innovation & Regulatory Science. 35 (1): 293–317. doi:10.1177/009286150103500134.
- 1 2 Sriram D, Yogeeswari P. Medicinal Chemistry, 2nd Edition. Pearson Education India, 2010. ISBN 9788131731444
- ↑ Auburn University course material. Jack DeRuiter, Principles of Drug Action 2, Fall 2002 1: Non-Steroidal Antiinflammatory Drugs (NSAIDS)
- ↑ Information for Healthcare Professionals: Celecoxib (marketed as Celebrex) http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm124655.htm
- ↑ "Safety of Vioxx". FDA Public Health Advisory. United States Food and Drug Administration.
- ↑ Alert for Healthcare Professionals: Valdecoxib (marketed as Bextra)
- ↑ Viljoen A, Mncwangi N, Vermaak I (2012). "Anti-inflammatory iridoids of botanical origin". Curr. Med. Chem. 19 (14): 2104–27. doi:10.2174/092986712800229005. PMC 3873812. PMID 22414102.
- ↑ Zhang L, Feng L, Jia Q, Xu J, Wang R, Wang Z, Wu Y, Li Y (2011). "Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro". Bioorg. Med. Chem. 19 (16): 4882–6. doi:10.1016/j.bmc.2011.06.069. PMID 21775152.
