Leuprorelin

Leuprorelin
Data klinis


Nama dagang	Divalin, Endrolin, Lupron, Eligard, Lucrin, Lupaneta, Tapros, dll
Nama lain	leuprolida, leuprolidina, A-43818, Abbott-43818, DC-2-269, TAP-144
AHFS/Drugs.com	monograph
MedlinePlus	a685040
License data	US DailyMed: Leuprolide
Kategori kehamilan	AU: D
Rute pemberian	Implan, subkutan, intramuskular
Kelas obat	GnRH analogue; GnRH agonist; Antigonadotropin
Kode ATC	L02AE02 (WHO)
Status hukum
Status hukum	AU: S4 (Prescription only) ^[1] CA: ℞-only ^[2]^[3] US: ℞-only ^[4]^[5]^[6]^[7]^[8] EU: Rx-only ^[9] ℞ (Hanya resep)
Data farmakokinetika
Waktu paruh eliminasi	3 jam
Ekskresi	Ginjal
Pengenal
Nama IUPAC N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminometilidenaamino)-1- [2-(etilkarbamoil)pirolidin-1-il]-1-okso-pentan-2- il]karbamoil]-3-metil-butil]karbamoil]-3-metil- butil]karbamoil]-2-(4-hidroksifenil)etil] karbamoil]-2-hidroksi-etil]karbamoil]-2-(1H-indol-3- il)etil]karbamoil]-2-(3H-imidazol-4-yl)ethyl]-5-oxo- pirolidina-2-karboksamida
Nomor CAS	53714-56-0^Y 74381-53-6 (asetat)
PubChem CID	657181
IUPHAR/BPS	1175
DrugBank	DB00007^Y
ChemSpider	571356^N
UNII	EFY6W0M8TG
KEGG	D08113^Y
ChEMBL	ChEMBL1201199^N
CompTox Dashboard (EPA)	DTXSID50872411
ECHA InfoCard	100.161.466
Data sifat kimia dan fisik
Rumus	C₅₉H₈₄N₁₆O₁₂
Massa molar	1.209,42 g·mol⁻¹
Model 3D (JSmol)	Gambar interaktif
SMILES CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3c[nH]c4c3cccc4)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@@H]6CCC(=O)N6
InChI InChI=1S/C59H84N16O12/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64)/t40-,41-,42-,43+,44-,45-,46-,47-,48-/m0/s1^N Key:GFIJNRVAKGFPGQ-LIJARHBVSA-N^N
^NY (what is this?) (verify)

Leuprorelin, juga disebut sebagai leuprolida, adalah sebuah versi yang diproduksi pabrik dari hormon yang dipakai untuk mengobati kanker prostat, kanker payudara, fibroid uterin dan pubertas awal.^[10]^[11] Obat tersebut diberikan lewat penyuntikan ke otot atau bagian dalam kulit.^[10]

Referensi

↑ ELIGARD (Mundipharma Pty Ltd) Department of Health and Aged Care. Retrieved 30 March 2023
↑ "Product monograph brand safety updates". Health Canada. February 2024. Diakses tanggal 24 March 2024.
↑ "Regulatory Decision Summary for Eligard". Drug and Health Products Portal. 21 September 2023. Diakses tanggal 2 April 2024.
↑
↑
↑
↑
↑
↑ "Camcevi EPAR". European Medicines Agency (EMA). 22 March 2022. Diakses tanggal 21 June 2022.
1 2 "Leuprolide Acetate". The American Society of Health-System Pharmacists. Diarsipkan dari asli tanggal 23 December 2016. Diakses tanggal 8 December 2016.
↑ "19th WHO Model List of Essential Medicines (April 2015)" (PDF). WHO. April 2015. Diarsipkan dari asli (PDF) tanggal May 13, 2015. Diakses tanggal May 10, 2015.

Pranala luar

Lupron Injection (package insert from abbott)
Reforming (purportedly) Non-Punitive Responses to Sexual Offending (journal article discussing use of Lupron as a form of reforming sex offender law)

Bacaan lebih lanjut

Shajnfeld A, Krueger RB (July 2006). "Reforming (Purportedly) Non-Punitive Responses to Sexual Offending". Developments in Mental Health Law. 25: 81. SSRN 1077282.

Artikel bertopik farmasi ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[1] ELIGARD (Mundipharma Pty Ltd) Department of Health and Aged Care. Retrieved 30 March 2023

[2] "Product monograph brand safety updates". Health Canada. February 2024. Diakses tanggal 24 March 2024.

[3] "Regulatory Decision Summary for Eligard". Drug and Health Products Portal. 21 September 2023. Diakses tanggal 2 April 2024.

[Lupron_FDA_label-4] ↑

[Eligard_FDA_label-5] ↑

[Fensolvi_FDA_label-6] ↑

[Viadur_FDA_label-7] ↑

[Lupron_Depot_FDA_label-8] ↑

[Camcevi_EPAR-9] "Camcevi EPAR". European Medicines Agency (EMA). 22 March 2022. Diakses tanggal 21 June 2022.

[AHFS2016-10] 1 2 "Leuprolide Acetate". The American Society of Health-System Pharmacists. Diarsipkan dari asli tanggal 23 December 2016. Diakses tanggal 8 December 2016.

[WHO2015E-11] "19th WHO Model List of Essential Medicines (April 2015)" (PDF). WHO. April 2015. Diarsipkan dari asli (PDF) tanggal May 13, 2015. Diakses tanggal May 10, 2015.

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Leuprorelin

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Leuprorelin

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